Results
| PMID | 18281042 |
| Gene Name | CXCL10 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 147 |
| Population details | 147 (77 with endometriosis, 70 without endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2009 Feb;91(2):331-4. doi: 10.1016/j.fertnstert.2007.11.075. Epub Galleri, Letizia| Luisi, Stefano| Rotondi, Mario| Romagnani, Paola| Cobellis, Luigi| Serio, Mario| Petraglia, Felice Division of Obstetrics and Gynecology, Department of Pediatrics, Gynecology and Reproductive Medicine, University of Siena, Siena, Italy. OBJECTIVE: To evaluate serum and peritoneal fluid concentrations of interferon-gamma-inducible protein-10 (CXCL10), a chemokine involved in local immune function, in women with endometriosis. DESIGN: Prospective study. SETTING: Division of Obstetrics and Gynecology, University of Siena. PATIENT(S): A total of 147 women were divided in two groups: women with (n = 77) and without (n = 70) endometriosis. INTERVENTION(S): Serum and peritoneal fluid were collected from all patients undergoing laparoscopy. MAIN OUTCOME MEASURE(S): CXCL10 concentrations were measured by a specific ELISA. RESULT(S): Serum CXCL10 concentrations in women with endometriosis were significantly lower than in those without endometriosis. No statistically significant difference between women with early endometriosis and those with advanced endometriosis was found. CXCL10 concentrations in peritoneal fluid of women with advanced endometriosis were significantly lower than in that of women with an early stage of, or without, endometriosis. CONCLUSION(S): The decreased concentrations of CXCL10 in serum and peritoneal fluid of women with endometriosis indicate an impaired immune activity in women with endometriosis. Mesh Terms: Ascitic Fluid/*immunology| Biomarkers/analysis| Case-Control Studies| Chemokine CXCL10/*analysis/blood| Down-Regulation| Endometriosis/*immunology/pathology| Enzyme-Linked Immunosorbent Assay| Female| Humans| Laparoscopy| Prospective Studies| S |
|